Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1
نویسندگان
چکیده
منابع مشابه
Antibodies induced with recombinant VP1 from human rhinovirus exhibit cross-neutralisation.
Human rhinoviruses (HRVs) are the major cause of the common cold and account for 30-50% of all acute respiratory illnesses. Although HRV infections are usually harmless and invade only the upper respiratory tract, several studies demonstrate that HRV is involved in the exacerbation of asthma. VP1 is one of the surface-exposed proteins of the viral capsid that is important for the binding of rhi...
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BACKGROUND Rhinoviruses (RVs) are a major cause of common colds and induce exacerbations of asthma and chronic inflammatory lung diseases. METHODS We expressed and purified recombinant RV coat proteins VP1-4, non-structural proteins as well as N-terminal fragments of VP1 from four RV strains (RV14, 16, 89, C) covering the three known RV groups (RV-A, RV-B and RV-C) and measured specific IgG-s...
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متن کاملThe application of prophylactic antibodies for rhinovirus infections.
Rhinoviruses are extremely common pathogens of the upper respiratory tract with adults experiencing on average 2-5 infections per year and children up to 12 infections. Although infections are not life threatening, except in cases of chronic lung disease where rhinoviruses are the major precipitant of acute exacerbations of disease, there is a high associated economic cost resulting from lost p...
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ژورنال
عنوان ژورنال: Antiviral Research
سال: 2012
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2012.06.006